Data Sovereign Humans and the Information Economy: Towards Design Principles for Human Centric B2C Data Ecosystems

The ever-growing amounts of data offer companies many opportunities for data-driven-value generation which, in turn, can be multiplied by leveraging data across company boundaries in evolving data ecosystems. However, while such systems increasingly emerge in B2B environments enabling systematic sharing and utilization of “industrial data”, comparable concepts in B2C ambits have not yet prevailed. Despite the rising importance of personal data in the information economy, B2C data ecosystems represent a widely unexplored research area. To remedy this gap, the study generates design principles for human centric B2C data ecosystems to aid in their development. For this purpose, a qualitative interview study with experts of interdisciplinary domains and a structured literature review are conducted both embedded into a methodology for generating design principles. On this basis, derived design principles help to understand peculiarities of data ecosystems in B2C ambits and provide solutions to overcome their obstacles identified in the empirical investigation

Theory of Electron-Phonon Dynamics in Insulating Nanoparticles

We discuss the rich vibrational dynamics of nanometer-scale semiconducting and insulating crystals as probed by localized electronic impurity states, with an emphasis on nanoparticles that are only weakly coupled to their environment. Two principal regimes of electron-phonon dynamics are distinguished, and a brief survey of vibrational-mode broadening mechanisms is presented. Recent work on the effects of mechanical interaction with the environment is discussed.Comment: Revte

Electron-Phonon Dynamics in an Ensemble of Nearly Isolated Nanoparticles

We investigate the electron population dynamics in an ensemble of nearly isolated insulating nanoparticles, each nanoparticle modeled as an electronic two-level system coupled to a single vibrational mode. We find that at short times the ensemble-averaged excited-state population oscillates but has a decaying envelope. At long times, the oscillations become purely sinusoidal about a ``plateau'' population, with a frequency determined by the electron-phonon interaction strength, and with an envelope that decays algebraically as t^-{1/2} We use this theory to predict electron-phonon dynamics in an ensemble of Y_2 O_3 nanoparticles.Comment: 11 pages, 3 figure

Quantization of Superflow Circulation and Magnetic Flux with a Tunable Offset

Quantization of superflow-circulation and of magnetic-flux are considered for systems, such as superfluid $^3$He-A and unconventional superconductors, having nonscalar order parameters. The circulation is shown to be the anholonomy in the parallel transport of the order parameter. For multiply-connected samples free of distributed vorticity, circulation and flux are predicted to be quantized, but generically to nonintegral values that are tunably offset from integers. This amounts to a version of Aharonov-Bohm physics. Experimental settings for testing these issues are discussed.Comment: 5 two-column pages, ReVTeX, figure available upon request (to [email protected]

Thromboembolism After Intramedullary Nailing for Metastatic Bone Lesions.

BACKGROUND: The risk of venous thromboembolism (VTE) in patients undergoing intramedullary nailing for skeletal metastatic disease is currently undefined. The purpose of our study was to determine the risk of thromboembolic events, to define the risk factors for VTE, and to define the rate of wound complications in this population. METHODS: A retrospective review of surgical databases at three National Cancer Institute (NCI)-designated cancer centers identified 287 patients with a total of 336 impending or pathologic long-bone fractures that were stabilized with intramedullary nailing between February 2001 and April 2013. Statistical analysis was performed utilizing multivariable logistic regression and Fisher exact tests. RESULTS: The overall rate of VTE was twenty-four (7.1%) of the 336; thirteen (3.9%) were pulmonary embolism (PE), and eleven (3.3%), deep venous thrombosis (DVT). In two patients, adequate anticoagulation data were not available. We found no significant relationship between the type of anticoagulant used and VTE. There was a significant positive correlation found between lung-cancer histology and the development of VTE (p \u3c 0.001) or PE (p \u3c 0.001). The absence of radiation therapy approached significance (p = 0.06) with respect to decreased overall VTE risk. Wound complications were documented for 11 (3.3%) of the operations. CONCLUSIONS: There is a high rate of VTE among those with skeletal metastatic disease who undergo intramedullary nailing, even while receiving postoperative thromboembolic prophylaxis. Current anticoagulation protocols may be inadequate. Wound-complication risk with anticoagulant use in this population is low and should not be a deterrent to adequate anticoagulant use for this population

High-throughput isolation and characterization of untagged membrane protein complexes: outer membrane complexes of Desulfovibrio vulgaris.

Cell membranes represent the "front line" of cellular defense and the interface between a cell and its environment. To determine the range of proteins and protein complexes that are present in the cell membranes of a target organism, we have utilized a "tagless" process for the system-wide isolation and identification of native membrane protein complexes. As an initial subject for study, we have chosen the Gram-negative sulfate-reducing bacterium Desulfovibrio vulgaris. With this tagless methodology, we have identified about two-thirds of the outer membrane- associated proteins anticipated. Approximately three-fourths of these appear to form homomeric complexes. Statistical and machine-learning methods used to analyze data compiled over multiple experiments revealed networks of additional protein-protein interactions providing insight into heteromeric contacts made between proteins across this region of the cell. Taken together, these results establish a D. vulgaris outer membrane protein data set that will be essential for the detection and characterization of environment-driven changes in the outer membrane proteome and in the modeling of stress response pathways. The workflow utilized here should be effective for the global characterization of membrane protein complexes in a wide range of organisms

Governance of Digital Health Data on Cooperatively Organized Platforms – a Design Thinking Approach

More and more stakeholders are collecting data for improving their services: from scientific research over public administration to commercial enterprises. Existing data management services offer few rights of co-determination for their users. Data cooperatives aim to provide a democratic alternative to this. Through such a platform cooperative members are supposed to be enabled to share their data in a self-determined way. In this paper, we present a design thinking-based user research with stakeholders of data cooperatives in a health-data context. We provide an overview of motivations, expectations, and interfaces between a cooperative and individuals as cooperative members, organizations, representatives from research, and policy makers. In an iterative process, 34 interviews were conducted with different stakeholder groups, from which 7 personas were subsequently derived. For these, 4 prototypes were developed and tested with potential users. Our results show that all interviewed groups were very interested in the concept of data cooperatives. At the same time, it proves challenging to reconcile the conflicting internal and external requirements and to implement attractive value propositions for all stakeholders

Banning the bulb: institutional evolution and the phased ban of incandescent lighting in Germany

Much academic attention has been directed at analysing energy efficiency investments through the lens of ‘behavioural failure’. These studies have challenged the neoclassical framing of regulation which emphasises the efficiency benefits of price based policy, underpinned by the notion of rational individual self-mastery. The increasing use of a regulatory ban on electric lamps in many countries is one of the most recent and high profile flash points in this dialectic of ‘freedom-versus-the-state’ in the public policy discourse. This paper interrogates this debate through a study of electric lamp diffusion in Germany. It is argued that neoclassical theory and equilibrium analysis is inadequate as a tool for policy analysis as it takes the formation of market institutions, such as existing regulations, for granted. Further still, it may be prone to encourage idealistic debates around such grand narratives which may in practice simply serve those who benefit most from the status quo. Instead we argue for an evolutionary approach which we suggest offers a more pragmatic framing tool which focuses on the formation of market institutions in light of shifting social norms and political goals—in our case, progress towards energy efficiency and environmental goals

Optical properties of quantum wires: Disorder-scattering in the Lloyd-model

The Lloyd model is extended to the exciton problem in quasi one-dimensional structures to study the interplay between the Coulomb attraction and disorder scattering. Within this model the averaging and resummation of the locator series can be performed analytically. As an application, the optical absorption in quantum box wires is investigated. Without electron-hole interaction, fluctuations in the well-width lead to an asymmetric broadening of the minibands with respect to the lower and upper band-edges.Comment: 7 pages, 6 figure